This is for the simple text copy pasting formate template for work file
8️⃣ Calcifying aponeurotic fibroma
9️⃣ Dermatomyofibroma 👇🏻✅✅
Plaque like CD-34 positive dermal fibroma 👇🏻
Angiomyofibroblastoma
Cellular angiofibroma 👇🏻
Elastofibroma
Inclusion body (digital) fibromatosis 👇🏻✅
Fibroma of tendon sheath 👇🏻
Fibroma of tendon sheath is well-circumscribed and has a lobular growth pattern like giant cell tumor of tendon sheath. The degree of cellularity is variable. There are hypocellular areas with sparse numbers of bland spindle cells in a dense collagenous stroma adjacent to zones of myxoid change containing stellate cells.
Desmoplastic fibroblastoma 👇🏻
Nuchal type fibroma 👇🏻
Palmar and plantar fibromatosis (superficial fibromatosis) 👇🏻✅
Penile fibromatosis 👇🏻✅
🔰 *Important note*
Soft tissue tumours is one of the imp chaps of rooks which usually comes in mcq exam and in opds as well.
Its difficult to memorize bcoz for diagnosis histopath is must to remember.
Thts y if any such questions comes in exam u can only diagnose it if u know the histopath of tht particular tumour or its IHC markers.
Dermatofibrosarcoma protuberans✅✅
🔰 Important tip👇🏻
Topics which are not recorded are not v imp.
U may practice mcqs only for those topics
Dimple sign
3️⃣ Atypical fibroxanthoma✅
🔰 Important tip👇🏻
Topics which are not recorded are not v imp.
U may practice mcqs only for those topics
Dimple sign
3️⃣ Atypical fibroxanthoma✅
🔰 This image came in our toacs exam
3️⃣ Pyogenic granuloma / Lobular capillary hemangioma✅
4️⃣ Kaposiform haemangioendothelioma✅
5️⃣ Angiosarcoma
🔰 IMPORTANT TIP FOR THIS CHAP👇🏻
✅ Marks imp topics from this chap “Soft tissue tumours”
2️⃣ Dilated pore
3️⃣ Tumour of follicular infundibulum
4️⃣ Pilar sheath acanthoma
5️⃣ Trichoadenoma
6️⃣ Comedo naevus
Pagets disease of the nipple✅
Extramammary paget disease
🔰 Imp exam slide
Pagets disease
1️⃣ Malignant eccrine poroma✅
2️⃣ Squamoid eccrine ductal carcinoma
3️⃣ Digital papillary adenocarcinoma
4️⃣ Malignant cylindroma
5️⃣ Hydradenocarcinoma
6️⃣ Spiradenocarcinoma
Spiradenoma✅
A very imp exam slide
Cylindroma✅
Mixed tumour of skin
Hidradenoma
Eccrine hydrocystoma
Syringoma✅
Apocrine carcinoma
🔰 *IMPORTANT NOTE*
For this chap, u must memorize the histopathology of imp topics which frequently comes in exam(which i have marked imp).
ETAS will help u to make the concept clear.
In the end, u ll only remember the points mentioned or explained in mcqs so spend more time in mcqs
Definition
Predisposing factors
Genetics
Environmental factors
Artificial sources of UV, sunbeds and PUVA
Histoclinical subtypes
Molecular classification
Clinical features
ABCDE
Diagnostic tools
SUPERFICIAL SPREADING MELANONA
NODULAR MELANOMA
LENTIGO MALIGNA MELANOMA
ACRAL LENTIGINOUS MELANOMA
SUBUNGUAL MELANOMA
MUCOSAL MELANOMA
OCULAR MELANOMA
AMELANOTIC MELANOMA
REGRESSIVE MELANOMA
MALIGNANT BLUE NAEVUS
SINONASAL MELANOMA
Strategies for early detection
Investigations
HISTOPATHOLOGICAL DIAGNOSIS
Immunohistochemistry
Prognostic markers
Biopsy
Staging of Primary melanoma
Follow up
Wide local excision of melanoma
Sentinel lymph node biopsy
Systemic treatment of melanoma
Systemic therapy for metastatic disease
Advanced stage IIIB/IIIC and stage IV disease
The mitogen-activated protein kinase (MAPK) pathway includes cascades of protein kinases which are activated by genotoxic stress and growth factors, including chemotherapeutic compounds. MAPK pathway activation stimulates the RAS oncogene, which stimulates RAF, consequently leading to ERK1/ERK2 cascade.
Chemotherapy
Summary of systemic rx
🔰 IMPORTANT TIP 👇🏻
🔰 DISORDERS OF DENTRITIC CELLS
1️⃣ Langerhans cell histiocytosis 👇🏻
(Most imp topic of this chap)
For revision go through tables
🔰 Revise Management from the Treatment ladder
🔰 Dendritic cell origin
👇🏻Disorders with mainly skin involvement
1️⃣ Juvenile xanthogranuloma
Touton giant cell is imp to remember along with markers
2️⃣ Benign cephalic histiocytosis
3️⃣ Generalized eruptive histiocytosis
4️⃣ Papular xanthoma
5️⃣ Progressive nodular histiocytosis
6️⃣ Xanthoma disseminatum
7️⃣ Diffuse plane xanthomatosis
👇🏻Disorders of skin with predominant skin involvement
1️⃣ Erdheim-Chester disease
Predominant skin involvement with/without systemic component👇🏻
1️⃣ Reticulohistiocytoma
2️⃣ Familial sea blue histiocytosis
3️⃣ Hereditary progressive mucinous histiocytosis
4️⃣ Malakoplakia
5️⃣ Necrobiosis xanthogranuloma
👇🏻Disorders with predominant systemic involvement and some skin involvement
1️⃣ Multicentric reticulohistiocytosis
🔰1 of the most imp topics of this chap. Very imp for theory and clinical slides. Imp differential too👆🏻
2️⃣ *Sinus histiocytosis with massive lymphadenopathy/ Rosai Dorfman disease*
2️⃣ True histiocytic lymphoma
3️⃣ Histiocytic sarcoma
🔰 Important topics to remember in this chap👇🏻
1. Benign keratinocytic acanthomas and proliferation
2. Cutaneous cysts
Solve mcqs only
🔰 Mycosis fungoides
🔰 *Important tip*
MF is the most imp topic of this chap, before exam this topic is a must to revise.
Make ua concept from above voice notes and then revise MF from long case group which is more refined and summarized.
Solve mcqs from various sources to make the concept even more clear.
Imp parts are clinical variants, markers, clinical presentation, staging, histopath and management.
Happy learning😊
Histopath of MF👆🏻
Sezary syndrome
🔰 All tables given in rooks in the section of MF are v imp.
They ll help u with quick revision
🔰 Subcutaneous panniculitis like T cell lymphoma
🔰 Primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma
🔰 Primary cutaneous gamma sigma T cell lymphoma
🔰 Primary cutaneous CD4+ small/medium sized pleomorphic T cell lymphoma
🔰 Adult T cell leukemia/lymphoma
🔰 Extranodal NK/ T cell lymphoma
1️⃣ *Intravascular large B cell lymphoma*
2️⃣ *Lymphomatoid granulomatosis*
Cutaneous manifestations of hodgkin’s disease
3️⃣ *Primary cutaneous B cell lymphomas*
4️⃣ *Marginal zone lymphoma*
5️⃣ *Follicle centre cell lymphoma*
Diffuse large cell lymphoma
*Recent advances in MF* treatment include:
– Histone deacetylase inhibitors (HDACi) like romidepsin and belinostat
– Immune checkpoint inhibitors like pembrolizumab and nivolumab
– Brentuximab vedotin (an antibody-drug conjugate)
– Mogamulizumab (a monoclonal antibody)
– Lenalidomide (an immunomodulatory agent
– zonalimunab (anti CD 4 antibody)
– alemtuzumab (anti CD 52)
💥FRECKLE/ EPHELIS
💥LENTIGINES
👇🏻Simple lentigo
👇🏻Solar or actinic lentigo
👇🏻PUVA lentigo
👇🏻Ink spot lentigo
💥MUCOSAL MELANOTIC LESIONS
👇🏻Pigmented melanotic macules
💥DERMAL MELANOCYTIC LESIONS
👇🏻Naevus of Ota
👇🏻Naevus of Ito
💥CONGENITAL MELANOCYTIC NAEVUS
👇🏻Speckled lentiginous naevus
💥 ACQUIRED MELANOCYTIC NAEVI
Naevus spilus👆🏻
Compound naevus👆🏻
Intradermal naevus👆🏻
💥 NAEVI IN UNUSUAL SITES
Melanocytic naevi of genital area
Acral naevi
Conjunctival naevi
Naevi of nail matrix or nail bed
💥 NAEVI WITH UNUSUAL MORPHOLOGY
Meyerson naevus
Cockade naevus
Targetoid haemosiderotic naevus
💥SPITZ NAEVUS
🔰 Histopath of spitz naevus is an important exam slide.
Atypical spitz naevus
Blue naevus and variants
🔰 Important tip for this chap👇🏻
For the identification of the type of a naevus, it is v imp tht u understand and remember its histopathology, so u must have a gud grip over it.
Its an imp exam slide too, both for slides and toacs station so prep it very well.
Happy learning😊